1-(1,3-苯并二氧代l-5-基)环丙烷羧酸合成路线 （共 4 条）
反应条件
1: With sodium hydroxide; water; N-benzyl-N,N,N-triethylammonium chloride T=70 - 130°C; 72 h; 2: With hydrogenchloride in water
参考文献
Ruah, Sara Hadida; Miller, Mark; Zhou, Jinglan; Bear, Brian
Patent: US2009/221597 A1, 2009 ;
Location in patent: Page/Page column 29 ;
US 20090221597 A1
反应条件
1: With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in water T=70 - 130°C; 112 h; 2: With hydrogenchloride in water pH=< 1;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/75435 A1, 2005 ;
Location in patent: Page/Page column 151-152 ;
WO 2005/075435 A1
反应条件
thionyl chloride in N,N-dimethyl-formamide
反应条件
thionyl chloride in N,N-dimethyl-formamide
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
