3-碘-1-异丙基-1H-吡唑并[3,4-D]嘧啶-4-胺合成路线 （共 4 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C; 2 h; Heating / reflux;
参考文献
Regents of the University of California
Patent: US2007/293516 A1, 2007 ;
Location in patent: Page/Page column 12; 16 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C;
参考文献
UNIVERSITY OF WASHINGTON; VAN VOORHIS, Wesley, C.; HOL, Wilhelmus, G.J.; LARSON, Eric, T.; MALY, Dustin, James; MERRITT, Ethan; OJO, Kayode, K.
Patent: WO2011/94628 A1, 2011 ;
Location in patent: Page/Page column 99 ;
WO 2011/094628 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20 - 200°C; Microwave irradiation;
参考文献
Klein, Michael; Diner, Peter; Dorin-Semblat, Dominique; Doerig, Christian; Grotli, Morten
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 17 p. 3421 - 3429
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=200°C; 0.0833333 h; Microwave irradiation; regioselective reaction;
参考文献
Diner, Peter; Alao, John P.; Soederlund, Johan; Sunnerhagen, Per; Grotli, Morten
Journal of Medicinal Chemistry, 2012 , vol. 55, # 10 p. 4872 - 4876
