potassium carbonate in methanol T=25°C; 4 h;

1: 82 percent / K2CO3 / methanol / 4 h / 25 °C 2: 84 percent / CuI; PPh3; iPr2NH / Pd(PPh3)2Cl2 / 16 h / 25 °C 3: 90 percent / KOH / methanol; H2O / 20 h / 25 °C 4: 98 percent / Cp2TiMe2 / toluene / 16 h / 110 °C 5: HCOOH; NEt3 / Noyori's catalyst / dimethylformamide / 7 h / 25 °C View Scheme

1: 82 percent / K2CO3 / methanol / 4 h / 25 °C 2: 84 percent / CuI; PPh3; iPr2NH / Pd(PPh3)2Cl2 / 16 h / 25 °C 3: 90 percent / KOH / methanol; H2O / 20 h / 25 °C 4: 98 percent / Cp2TiMe2 / toluene / 16 h / 110 °C 5: HCOOH; NEt3 / Noyori's catalyst / dimethylformamide / 7 h / 25 °C View Scheme

1: 82 percent / K2CO3 / methanol / 4 h / 25 °C 2: 84 percent / CuI; PPh3; iPr2NH / Pd(PPh3)2Cl2 / 16 h / 25 °C 3: 90 percent / KOH / methanol; H2O / 20 h / 25 °C 4: 98 percent / Cp2TiMe2 / toluene / 16 h / 110 °C View Scheme

1.1: 82 percent / K2CO3 / methanol / 4 h / 25 °C 2.1: 84 percent / CuI; PPh3; iPr2NH / Pd(PPh3)2Cl2 / 16 h / 25 °C 3.1: 90 percent / KOH / methanol; H2O / 20 h / 25 °C 4.1: 98 percent / Cp2TiMe2 / toluene / 16 h / 110 °C 5.1: HCOOH; NEt3 / Noyori's catalist / dimethylformamide / 7 h / 25 °C 5.2: methanol; H2O / 3 h / 25 °C 5.3: NaBH4 / methanol; H2O / 16 h / 25 °C View Scheme