1: acetylene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: tert-butyldimethylsilyl chloride in tetrahydrofuran; hexane T=20°C; 24 h; Further stages.;

in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide 8 h; Heating;

n-butyllithium Alkylation; hydroxymethylation;

1: tert-butyldimethylsilyl acetylene With hydroxylamine hydrochloride; N-butylamine; copper(l) chloride in water cooling; 2: 1-bromo-2-phenylacetylene With hydroxylamine hydrochloride in diethyl ether; water Cadiot-Chodkiewicz cross-coupling; Further stages.;

RuCl2(tricyclohexylphosphine)2(benzylidene); water in benzene-d6 T=40°C; Inert atmosphere;

1: tert-butyldimethylsilyl acetylene With n-butyllithium in tetrahydrofuran T=0°C; 0.333333 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=0°C; Reflux;