1: 4-(3-bromophenyl)morpholine With n-butyllithium in tetrahydrofuran; hexane T=-78 - -70°C; 2 h; 2: tri-isopropoxy-borane in tetrahydrofuran; hexane T=20°C; Cooling with acetone-dry ice; 3: With water; ammonium chloride in tetrahydrofuran; hexane

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tris-(dibenzylideneacetone)dipalladium(0); (R)-1,1'-bis(diphenylphosphino)-2,2'-binapthyl / toluene / 60 °C / Inert atmosphere 1.2: 100 °C 2.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 - -70 °C 2.2: 20 °C / Cooling with acetone-dry ice View Scheme