1-[(3-氯-4-氟苯基)羰基]氮杂丁烷合成路线 （共 3 条）
反应条件
1: 3-chloro-4-fluoro-benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=18 - 25°C; 16 h;
2: azetidine hydrochloride With triethylamine in dichloromethane
T=18 - 25°C; 2 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/17649 A1, 2007 ;
Location in patent: Page/Page column 43-44 ;
WO 2007/017649 A1
反应条件
triethylamine in dichloromethane
T=18 - 25°C; 2 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/80360 A1, 2005 ;
Location in patent: Page/Page column 95 ;
WO 2005/080360 A1
反应条件
triethylamine in dichloromethane
T=20°C; 2 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/121110 A1, 2005 ;
Location in patent: Page/Page column 107 ;
WO 2005/121110 A1
