1: With hydrogen; palladium on activated carbon in methanol; water T=44 - 46°C; P=1575.16 Torr; 1.5 h; 2: With hydrogenchloride in water T=-10 - 42°C; 2.5 - 3 h;

1: With ammonia in ethanol; water T=120°C; 2 h; AutoclaveLarge scale; 2: With hydrogenchloride in water; acetone pH=6; Large scale;

hydrogenchloride in water; toluene

1.1: triethylamine; Pd0(tris(tert-butyl)phosphine)2 / acetonitrile; 2-methyl tetrahydrofuran / 0.58 h / 80 °C / |Inert atmosphere 2.1: DBBA; hydrogenchloride / tetrahydrofuran; water / 0.5 h / 60 - 65 °C / |Large scale 3.1: ammonia / water; ethanol / 2 h / 120 °C / |Autoclave; |Large scale 3.2: pH 6 / |Large scale View Scheme

1.1: DBBA; hydrogenchloride / tetrahydrofuran; water / 0.5 h / 60 - 65 °C / |Large scale 2.1: ammonia / water; ethanol / 2 h / 120 °C / |Autoclave; |Large scale 2.2: pH 6 / |Large scale View Scheme

1.1: water; sodium hydrogencarbonate; [Rh(NCMe)2(cod)][BF4] / tetrahydrofuran; methanol / 20 - 40 °C / |Inert atmosphere 2.1: DBBA; hydrogenchloride / tetrahydrofuran; water / 0.5 h / 60 - 65 °C / |Large scale 3.1: ammonia / water; ethanol / 2 h / 120 °C / |Autoclave; |Large scale 3.2: pH 6 / |Large scale View Scheme

sodium hydroxide in water; acetone T=55 - 60°C; 1 h;