5-氯-2-(4,4,5,5-四甲基-1,3,2-二氧硼烷)-苯胺合成路线 （共 8 条）
反应条件
triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane
T=100°C; 10.5 h;
参考文献
Japan Tobacco, Inc.
Patent: EP1719773 A1, 2006 ;
Location in patent: Example 1-10 ;
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium acetate; 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane in dimethyl sulfoxide
T=85°C; Inert atmosphere;
参考文献
CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; GEHLING, Victor, S.; TAYLOR, Alexander, M.; VASWANI, Rishi, G.
Patent: WO2013/184878 A1, 2013 ;
Location in patent: Paragraph 00183; 00184 ;
反应条件
bis(η4-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I); 4,4'-di-tert-butyl-2,2'-dipyridyl in tetrahydrofuran; dichloromethane
T=80°C; 8 h; Inert atmosphereGlovebox; SolventReagent/catalyst; regioselective reaction;
参考文献
Preshlock, Sean M.; Plattner, Donald L.; Maligres, Peter E.; Krska, Shane W.; Maleczka Jr., Robert E.; Smith III, Milton R.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 49 p. 12915 - 12919
Angew. Chem., 2013 , vol. 125, # 49 p. 13153 - 13157,5
反应条件
bis(η4-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I); 4,4'-di-tert-butyl-2,2'-dipyridyl in dichloromethane; cyclohexane
T=80°C; 8 h; Inert atmosphereGlovebox; SolventReagent/catalyst; regioselective reaction;
参考文献
Preshlock, Sean M.; Plattner, Donald L.; Maligres, Peter E.; Krska, Shane W.; Maleczka Jr., Robert E.; Smith III, Milton R.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 49 p. 12915 - 12919
Angew. Chem., 2013 , vol. 125, # 49 p. 13153 - 13157,5
反应条件
bis(η4-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I); 3,4,7,8-tetra-methyl-1,10-phenanthroline in dichloromethane; cyclohexane
T=80°C; 8 h; Inert atmosphereGlovebox; SolventReagent/catalyst; regioselective reaction;
参考文献
Preshlock, Sean M.; Plattner, Donald L.; Maligres, Peter E.; Krska, Shane W.; Maleczka Jr., Robert E.; Smith III, Milton R.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 49 p. 12915 - 12919
Angew. Chem., 2013 , vol. 125, # 49 p. 13153 - 13157,5
反应条件
bis(η4-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I); 3,4,7,8-tetra-methyl-1,10-phenanthroline in tetrahydrofuran; dichloromethane
T=80°C; 8 h; Inert atmosphereGlovebox; SolventReagent/catalyst; regioselective reaction;
参考文献
Preshlock, Sean M.; Plattner, Donald L.; Maligres, Peter E.; Krska, Shane W.; Maleczka Jr., Robert E.; Smith III, Milton R.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 49 p. 12915 - 12919
Angew. Chem., 2013 , vol. 125, # 49 p. 13153 - 13157,5
反应条件
1: With bis(η4-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I); 3,4,7,8-tetra-methyl-1,10-phenanthroline in tetrahydrofuran
T=80°C; 16 h; Inert atmosphereGlovebox;
2: With methanol in tetrahydrofuran
T=20°C; Inert atmosphereGlovebox;
参考文献
Preshlock, Sean M.; Plattner, Donald L.; Maligres, Peter E.; Krska, Shane W.; Maleczka Jr., Robert E.; Smith III, Milton R.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 49 p. 12915 - 12919
Angew. Chem., 2013 , vol. 125, # 49 p. 13153 - 13157,5
反应条件
1.1: tetrahydrofuran / 1 h / 20 °C / |Inert atmosphere; |Glovebox
2.1: bis(η4-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I); 3,4,7,8-tetra-methyl-1,10-phenanthroline / tetrahydrofuran / 16 h / 80 °C / |Inert atmosphere; |Glovebox
2.2: 20 °C / |Inert atmosphere; |Glovebox
View Scheme
参考文献
Preshlock, Sean M.; Plattner, Donald L.; Maligres, Peter E.; Krska, Shane W.; Maleczka Jr., Robert E.; Smith III, Milton R.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 49 p. 12915 - 12919
Angew. Chem., 2013 , vol. 125, # 49 p. 13153 - 13157,5
