1-(4-溴苯基)-3-氮杂双环[3.1.0]己烷-3-羧酸叔丁酯合成路线 （共 4 条）
反应条件
triethylamine in dichloromethane
T=0°C; 2 h;
参考文献
PANACEA BIOTEC LTD.; JAIN, Rajesh; TREHAN, Sanjay; DAS, Jagattaran; KAUR, Gurmeet; KANWAR, Sandeep; SINGH, Nishan; NANDA, Gurmeet Kaur; MAGADI, Sitaram Kumar; SHARMA, Sudhir Kumar
Patent: WO2010/150281 A2, 2010 ;
Location in patent: Page/Page column 63 ;
反应条件
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -10 °C
1.2: 4 h / -10 - 20 °C
2.1: dimethylsulfide borane complex; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 80 °C
2.2: 0 °C
2.3: pH 8
3.1: thionyl chloride / anhydrous dichloroethane / 2 h / 0 - 20 °C
3.2: 0 °C / pH 8
4.1: triethylamine / dichloromethane / 2 h / 0 °C
View Scheme
参考文献
PANACEA BIOTEC LTD.
Patent: US2012/165320 A1, 2012 ;
反应条件
1.1: dimethylsulfide borane complex; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 80 °C
1.2: 0 °C
1.3: pH 8
2.1: thionyl chloride / anhydrous dichloroethane / 2 h / 0 - 20 °C
2.2: 0 °C / pH 8
3.1: triethylamine / dichloromethane / 2 h / 0 °C
View Scheme
参考文献
PANACEA BIOTEC LTD.
Patent: US2012/165320 A1, 2012 ;
反应条件
1.1: thionyl chloride / anhydrous dichloroethane / 2 h / 0 - 20 °C
1.2: 0 °C / pH 8
2.1: triethylamine / dichloromethane / 2 h / 0 °C
View Scheme
参考文献
PANACEA BIOTEC LTD.
Patent: US2012/165320 A1, 2012 ;
