potassium hydroxide in tert-butyl alcohol Heating;

1: α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazol-1-ethanol With pyridine; phosphorus trichoride in dichloromethane T=-13 - 13°C; 2.08333 h; Inert atmosphereIndustrial scale; 2: benzyl alcohol in dichloromethane T=10 - 16°C; 4 h; Inert atmosphereIndustrial scale; 3: With dihydrogen peroxide in dichloromethane; water T=0 - 20°C; 4 h; Industrial scale;

1: 1H-tetrazole / dichloromethane / 2 h / 20 °C / |Inert atmosphere 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 20 °C / |Inert atmosphere View Scheme

T=750°C; Gas phase;

dihydrogen peroxide 3 h; Reflux;

T=750°C; Gas phase;

1.1: phosphorus trichoride; pyridine / dichloromethane / 2.08 h / -13 - 13 °C / |Inert atmosphere; |Industrial scale 1.2: 4 h / 10 - 16 °C / |Inert atmosphere; |Industrial scale 1.3: 4 h / 0 - 20 °C / |Industrial scale 2.1: hydrogen; sodium hydroxide; 5 palladium on charcoal / water / 12 h / 20 °C / 3105.31 Torr / |Industrial scale View Scheme

T=500°C; Gas phase;

T=750°C; Gas phase;

T=500°C; Gas phase;