1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C 2: Rongalit; sodium hydroxide / 1,4-dioxane / 0.5 h / 55 - 60 °C / |Inert atmosphere 3: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; tert.-butylhydroperoxide / dichloromethane; n-heptane / 8 h / -20 °C / |Inert atmosphere 4: potassium carbonate / tetrahydrofuran / 48 h / |Reflux View Scheme

1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C 2: Rongalit; sodium hydroxide / 1,4-dioxane / 0.5 h / 55 - 60 °C / |Inert atmosphere 3: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; tert.-butylhydroperoxide / dichloromethane; n-heptane / 8 h / -20 °C / |Inert atmosphere View Scheme

n-butyllithium; potassium carbonate in N-methyl-acetamide; methanol; diethyl ether; hexane; dichloromethane; water; acetic acid

1: 1H-1,2,4-triazol With potassium carbonate in N,N-dimethyl-formamide 1 h; Heating; 2: 1,3-(dichloro)-2-(2,4-difluorophenyl)propan-2-ol in N,N-dimethyl-formamide 16 h; Heating;

1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C 2: Rongalit; sodium hydroxide / 1,4-dioxane / 0.5 h / 55 - 60 °C / |Inert atmosphere View Scheme

sodium hydride in N,N-dimethyl-formamide T=0 - 20°C;