1-[2-(2,4-二氟苯基)-2,3-环氧基丙基]-1H-1,2,4-噻唑合成路线 （共 12 条）
反应条件
sodium hydroxide in toluene T=80°C; Corey-Chaykovsky epoxidation; 0.833333 h; microwave irradiation;
参考文献
Lebouvier, Nicolas; Giraud, Francis; Corbin, Typhanie; Na, Young Min; Le Baut, Guillaume; Marchand, Pascal; Le Borgne, Marc
Tetrahedron Letters, 2006 , vol. 47, # 36 p. 6479 - 6483
反应条件
sodium hydroxide in toluene T=60°C;
参考文献
Wang, Yan; Damu, Guri L.V.; Lv, Jing-Song; Geng, Rong-Xia; Yang, Da-Cheng; Zhou, Cheng-He
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 17 p. 5363 - 5366
反应条件
1: trimethylsulfoxonium iodide With sodium hydride in dimethyl sulfoxide 1 h; 2: 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one in dimethyl sulfoxide T=20°C; 12 h;
参考文献
WO2005/14583 A1, ;
Page/Page column 21-22 ;
反应条件
sodium hydroxide in toluene T=60°C; 3 h;
参考文献
Chai, Xiaoyun; Zhang, Jun; Hu, Honggang; Yu, Shichong; Sun, Qingyan; Dan, Zhigang; Jiang, Yuanying; Wu, Qiuye
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 5 p. 1913 - 1920
反应条件
trimethylsulfoxonium iodide; cetylmonomethylammonium bromide; sodium hydroxide in toluene T=60°C; 3 h;
参考文献
Chai, Xiaoyun; Yu, Shichong; Jiang, Yongwei; Zou, Yan; Wu, Qiuye; Zhang, Dazhi; Jiang, Yuanying; Cao, Yongbing; Sun, Qingyan
Archives of Pharmacal Research, 2012 , vol. 35, # 11 p. 1895 - 1901
反应条件
1: 99 percent / K2CO3 / acetonitrile / 0.83 h / 85 °C / microwave irradiation 2: 97 percent / aq. NaOH / toluene / 0.83 h / 80 °C / microwave irradiation View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 36 p. 6479 - 6483
反应条件
1: CH2Cl2 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 8 p. 2512 - 2525
反应条件
sodium hydroxide; N-hexadecyl-N,N,N-trimethylammonium bromide in toluene T=60°C; 3 h;
参考文献
Phosphorus, Sulfur and Silicon and the Related Elements, , vol. 179, # 11 p. 2329 - 2334
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 51, # 9 p. 1113 - 1116
反应条件
potassium carbonate in acetonitrile T=60°C;
参考文献
Zhang, Yi-Yi; Mi, Jia-Li; Zhou, Cheng-He; Zhou, Xiang-Dong
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 4391 - 4402
