二乙基氨基甲酸(3-溴苯基)酯合成路线 （共 14 条）
反应条件
1.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 84 percent / iodine / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 89 percent / NaOH / ethanol / Heating
3.1: 72 percent / piperidine; CuI / Pd(OAc)2(PPh3)2 / dimethylformamide / 5 h / 60 °C
View Scheme
参考文献
Sanz, Roberto; Castroviejo, M. Pilar; Fernandez, Yolanda; Fananas, Francisco J.
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6548 - 6551
反应条件
1.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 84 percent / I2 / tetrahydrofuran; hexane / -78 - 20 °C
2.1: NaOH / ethanol / Heating
3.1: 2.50 g / K2CO3 / acetonitrile / Heating
View Scheme
参考文献
Sanz, Roberto; Castroviejo, M. Pilar; Guilarte, Veronica; Perez, Antonio; Fananas, Francisco J.
Journal of Organic Chemistry, 2007 , vol. 72, # 14 p. 5113 - 5118
反应条件
Multi-step reaction with 3 steps 1.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C2.1: sodium hydroxide / ethanol / Reflux3.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere3.2: 2 h / 20 °C / Inert atmosphere
参考文献
Guilarte, Veronica; Castroviejo, M. Pilar; Garcia-Garcia, Patricia; Fernandez-Rodriguez, Manuel A.; Sanz, Roberto Journal of Organic Chemistry, 2011 , vol. 76, # 9 p. 3416 - 3437
反应条件
Multi-step reaction with 4 steps 1.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C2.1: sodium hydroxide / ethanol / Reflux3.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere3.2: 2 h / 20 °C / Inert atmosphere4.1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere
参考文献
Guilarte, Veronica; Castroviejo, M. Pilar; Garcia-Garcia, Patricia; Fernandez-Rodriguez, Manuel A.; Sanz, Roberto Journal of Organic Chemistry, 2011 , vol. 76, # 9 p. 3416 - 3437
