2,3-二溴-N,N-二乙基氨基甲酸苯酯合成路线 （共 6 条）
反应条件
1.1: sodium hydroxide / ethanol / Reflux 2.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere 2.2: 2 h / 20 °C / Inert atmosphere 3.1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere 4.1: hydrogenchloride / ethanol; water / Reflux View Scheme
参考文献
Guilarte, Veronica; Castroviejo, M. Pilar; Garcia-Garcia, Patricia; Fernandez-Rodriguez, Manuel A.; Sanz, Roberto
Journal of Organic Chemistry, 2011 , vol. 76, # 9 p. 3416 - 3437
反应条件
sodium hydroxide in ethanol Heating;
参考文献
Sanz, Roberto; Castroviejo, M. Pilar; Fernandez, Yolanda; Fananas, Francisco J.
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6548 - 6551
反应条件
1: With 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran
T=-78°C; 1 h;
2: With ethylene dibromide in tetrahydrofuran
T=-78 - 20°C; 0.5 h;
参考文献
Brown, Neil; Buszek, Keith R.
Tetrahedron Letters, 2012 , vol. 53, # 31 p. 4022 - 4025
反应条件
1.1: NaH / tetrahydrofuran / 2 h / 20 °C
1.2: 91 percent / tetrahydrofuran / 8 h / 20 °C
2.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 71 percent / 1,2-dibromoethane / tetrahydrofuran; hexane / -78 - 20 °C
View Scheme
参考文献
Sanz, Roberto; Castroviejo, M. Pilar; Fernandez, Yolanda; Fananas, Francisco J.
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6548 - 6551
反应条件
1.1: NaH / tetrahydrofuran / 2 h / 20 °C
1.2: 91 percent / tetrahydrofuran / 8 h / 20 °C
2.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 71 percent / 1,2-dibromoethane / tetrahydrofuran; hexane / -78 - 20 °C
View Scheme
参考文献
Sanz, Roberto; Castroviejo, M. Pilar; Fernandez, Yolanda; Fananas, Francisco J.
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6548 - 6551
反应条件
1.1: pyridine / 48 h / 100 °C
2.1: 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran / 1 h / -78 °C
2.2: 0.5 h / -78 - 20 °C
View Scheme
参考文献
Brown, Neil; Buszek, Keith R.
Tetrahedron Letters, 2012 , vol. 53, # 31 p. 4022 - 4025
