2-氨基-4-甲氧基-7-(beta-d-2-脱氧核糖)吡咯并[2,3-d]嘧啶合成路线 （共 8 条）
反应条件
trimethylsilyl iodide
参考文献
Ramasamy; Imamura; Robins; Revankar
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1893 - 1898
反应条件
in methanol
1 h; Heating;
参考文献
Ramasamy; Imamura; Robins; Revankar
Tetrahedron Letters, 1987 , vol. 28, # 43 p. 5107 - 5110
反应条件
DOWEX 550A
2 h; Heating;
参考文献
Jain, Moti L.; Bruice, Thomas C.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 21 p. 7333 - 7346
反应条件
1.1: sodium hydride / acetonitrile / 1 h / 20 °C
1.2: 78 percent / acetonitrile / 3 h / 20 °C
2.1: 93 percent / Dowex 550A / 2 h / Heating
View Scheme
参考文献
Jain, Moti L.; Bruice, Thomas C.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 21 p. 7333 - 7346
反应条件
1: 1) sodium hydride (60percent in oil) / 1) acetonitrile, RT, 0.5 h; 2) acetonitrile, RT, 2 h
2: 86 percent / methanol / 1 h / Heating
View Scheme
参考文献
Ramasamy; Imamura; Robins; Revankar
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1893 - 1898
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in dichloromethane
Ambient temperatureliquid-liquid phase-transfer glycosylation; Yield given;
参考文献
Seela, Frank; Westermann, Bernhard; Bindig, Uwe
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 697 - 702
反应条件
1.1: sodium hydride / acetonitrile / 1 h / 20 °C
1.2: 78 percent / acetonitrile / 3 h / 20 °C
2.1: 93 percent / Dowex 550A / 2 h / Heating
View Scheme
参考文献
Jain, Moti L.; Bruice, Thomas C.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 21 p. 7333 - 7346
反应条件
sodium hydroxide; ammonia; Aliquatreg; 336
1.) C6H6, dimethoxyethane, 2.) CH3OH, 24 h, room temp.; Yield given. Multistep reaction;
参考文献
Winkeler, Heinz-Dieter; Seela, Frank
Journal of Organic Chemistry, 1983 , vol. 48, # 18 p. 3119 - 3122
