2-(二叔丁基膦甲基-6-二乙氨基甲基)吡啶合成路线 （共 3 条）
反应条件
1: 2-diethylaminomethyl-6-methylpyridine With n-butyllithium in diethyl ether; hexane
T=0°C; 2 h;
2: chlorodi-tert-butylphosphine in diethyl ether; hexane
T=-78 - 20°C;
参考文献
Zhang, Jing; Leitus, Gregory; Ben-David, Yehoshoa; Milstein, David
Journal of the American Chemical Society, 2005 , vol. 127, # 31 p. 10840 - 10841
反应条件
1.1: NBS; 2,2'-azobisisobutyrlnitrile / CCl4 / 7 h
2.1: 17.5 g / tetrahydrofuran / 0 - 20 °C
3.1: n-BuLi / diethyl ether; hexane / 2 h / 0 °C
3.2: 70 percent / diethyl ether; hexane / -78 - 20 °C
View Scheme
参考文献
Zhang, Jing; Leitus, Gregory; Ben-David, Yehoshoa; Milstein, David
Journal of the American Chemical Society, 2005 , vol. 127, # 31 p. 10840 - 10841
反应条件
1.1: 17.5 g / tetrahydrofuran / 0 - 20 °C
2.1: n-BuLi / diethyl ether; hexane / 2 h / 0 °C
2.2: 70 percent / diethyl ether; hexane / -78 - 20 °C
View Scheme
参考文献
Zhang, Jing; Leitus, Gregory; Ben-David, Yehoshoa; Milstein, David
Journal of the American Chemical Society, 2005 , vol. 127, # 31 p. 10840 - 10841
