4-溴- 1 -甲基- 1H-咪唑-2 -羧酸甲酯合成路线 （共 3 条）
反应条件
1: 2-trichloroacetyl-N-methyl-1H-imidazole With N-bromosuccinmide in tetrahydrofuran
T=-10 - 20°C; 14 h;
2: methanol With sodium hydride
T=75°C; 1 h;
参考文献
AMGEN INC.
Patent: WO2009/75874 A1, 2009 ;
Location in patent: Page/Page column 132 ;
WO 2009/075874 A1
反应条件
in methanol
T=25°C; 0.333333 h;
参考文献
Billedeau, Roland Joseph; Kondru, Rama K.; Lopez-Tapia, Francisco Javier; Lou, Yan; Owens, Timothy D.; Qian, Yimin; So, Sung-Sau; Thakkar, Kshitij C.; Wanner, Jutta
Patent: US2012/295885 A1, 2012 ;
Location in patent: Page/Page column 32 ;
反应条件
1: N-bromosuccinmide / tetrahydrofuran / 18 h / -10 - 25 °C
2: methanol / 0.33 h / 25 °C
View Scheme
参考文献
Billedeau, Roland Joseph; Kondru, Rama K.; Lopez-Tapia, Francisco Javier; Lou, Yan; Owens, Timothy D.; Qian, Yimin; So, Sung-Sau; Thakkar, Kshitij C.; Wanner, Jutta
Patent: US2012/295885 A1, 2012 ;
