2-氯-5,6-二甲氧基-苯并噻唑合成路线 （共 2 条）
反应条件
tert.-butylnitrite; copper dichloride in acetonitrile
Sandmeyer reaction;
参考文献
Metten, Bert; Smet, Mario; Boens, Noel; Dehaen, Wim
Synthesis, 2005 , # 11 art. no. T13704SS, p. 1838 - 1844
反应条件
1.1: 11.5 percent / Br2; AcOH / 10 h / 35 °C
2.1: NaNO2; aq. H3PO4 / 0.5 h
2.2: 31.7 percent / CuSO4*5H2O; aq. NaCl / 1 h / -5 °C
View Scheme
参考文献
Buchholz, Mirko; Heiser, Ulrich; Schilling, Stephan; Niestroj, Andre J.; Zunkel, Katrin; Demuth, Hans-Ulrich
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 664 - 677
