5-（叔丁氧酰胺基）噻唑-4-甲酸乙酯合成路线 （共 5 条）
反应条件
N-iodo-succinimide in N,N-dimethyl-formamide T=60°C; 54 h;
参考文献
MERCK and CO., INC.; MACHACEK, Michelle, R.; HAIDLE, Andrew; ZABIEREK, Anna, A.; KONRAD, Kaleen, M.; ALTMAN, Michael, D.
Patent: WO2010/11375 A2, 2010 ;
Location in patent: Page/Page column 64 ;
WO 2010/011375 A2
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile
参考文献
Cui, Yong-Mei; Huang, Qing-Qing; Xu, Jie; Chen, Ling-Ling; Li, Jing-Ya; Ye, Qi-Zhuang; Li, Jia; Nan, Fa-Jun
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 16 p. 3732 - 3736
反应条件
1: acetic anhydride / tetrahydrofuran / 21 h / 0 - 55 °C
2: pyridine; Lawesson's reagent / 16 h / 20 - 120 °C
3: acetonitrile / 68 h / 20 °C
View Scheme
参考文献
NOVARTIS AG; BURGER, Matthew; DING, Yu; HAN, Wooseok; NISHIGUCHI, Gisele; RICO, Alice; SIMMONS, Robert Lowell; TANNER, Huw; WAN, Lifeng
Patent: WO2014/33630 A1, 2014 ;
反应条件
1: water; sodium dithionite; sodium carbonate / 1 h / 20 °C
2: acetic anhydride / tetrahydrofuran / 21 h / 0 - 55 °C
3: pyridine; Lawesson's reagent / 16 h / 20 - 120 °C
4: acetonitrile / 68 h / 20 °C
View Scheme
参考文献
NOVARTIS AG; BURGER, Matthew; DING, Yu; HAN, Wooseok; NISHIGUCHI, Gisele; RICO, Alice; SIMMONS, Robert Lowell; TANNER, Huw; WAN, Lifeng
Patent: WO2014/33630 A1, 2014 ;
反应条件
1: pyridine; Lawesson's reagent / 16 h / 20 - 120 °C
2: acetonitrile / 68 h / 20 °C
View Scheme
参考文献
NOVARTIS AG; BURGER, Matthew; DING, Yu; HAN, Wooseok; NISHIGUCHI, Gisele; RICO, Alice; SIMMONS, Robert Lowell; TANNER, Huw; WAN, Lifeng
Patent: WO2014/33630 A1, 2014 ;
