2-羟基-6-甲基吡啶-4-羧酸合成路线 （共 14 条）
反应条件
hydrogenchloride in water 21 h; Reflux;
参考文献
Schmidt, Gunther; Reber, Stefan; Bolli, Martin H.; Abele, Stefan
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 595 - 604
反应条件
1: piperidine; ethanol 2: aqueous HCl View Scheme
参考文献
Bulletin de la Societe Chimique de France, , p. 687,691
反应条件
1: methanol / 1.25 h / 60 °C 2: hydrogenchloride / water / 21 h / Reflux View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 4 p. 595 - 604
参考文献
Journal of the Indian Chemical Society, , vol. 7, p. 481,493
参考文献
Annali di Chimica (Rome, Italy), , vol. 47, p. 385,391
反应条件
1: 1,2-dihydro-6-methyl-2-oxo-4-pyridinecarboxylic acid With trichlorophosphate 18 h; Reflux; 2: methanol T=20°C; 24 h; Cooling with ice bath;
参考文献
DU PREEZ, Jan Gysbert Hermanus; WENTZEL, Mauritz; KNOETZE, Steyn
Patent: WO2012/153253 A2, 2012 ;
Location in patent: Page/Page column 67 ;
反应条件
phosphorus pentachloride; trichlorophosphate Behandeln des Reaktionsprodukts mit Methanol;
参考文献
Dulla, Balakrishna; Wan, Baojie; Franzblau, Scott G.; Kapavarapu, Ravikumar; Reiser, Oliver; Iqbal, Javed; Pal, Manojit
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4629 - 4635
反应条件
1: POCl3; PCl5 / Behandeln des Reaktionsprodukts mit Methanol 2: methanol; N2H4+H2O View Scheme
参考文献
Isler et al.
Helvetica Chimica Acta, 1955 , vol. 38, p. 1046,1058
参考文献
Musante; Fatutta
Annali di Chimica (Rome, Italy), 1957 , vol. 47, p. 385,391
反应条件
1: POCl3; PCl5 / Behandeln des Reaktionsprodukts mit Methanol 2: palladium/charcoal; methanol; potassium acetate / Hydrogenation 3: methanol. KOH View Scheme
参考文献
Isler et al.
Helvetica Chimica Acta, 1955 , vol. 38, p. 1046,1058
