1-(2-吡嗪)-3-甲基-1-丁酮合成路线 （共 4 条）
反应条件
in tert-butyl alcohol; benzene 4 h; Irradiation;
参考文献
Journal of the American Chemical Society, , vol. 114, # 5 p. 1838 - 1843
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane
T=-60 - -50°C;
2: With triethylamine in dichloromethane
T=-55 - 20°C;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; JIMENEZ, Juan-Miguel; STUDLEY, John
Patent: WO2010/11772 A2, 2010 ;
Location in patent: Page/Page column 112 ;
WO 2010/011772 A2
反应条件
tert.-butylhydroperoxide; sodium sulfite in sulfuric acid; water
参考文献
Philip Morris Incorporated
Patent: US4588813 A1, 1986 ;
反应条件
tert.-butylhydroperoxide; sulfuric acid; iron(II) sulfate in water
T=3 - 15°C; 1 h;
参考文献
Houminer, Y.; Southwick, E. W.; Williams, D. L.
Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 497 - 500
