3-(4-氨基苯基)-1,2,4-恶二唑-5(2H)-酮合成路线 （共 5 条）
反应条件
sodium carbonate in water; isopropyl alcohol T=20°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/71742 A1, 2007 ;
Location in patent: Page/Page column 21 ;
反应条件
sodium ethanolate in ethanol
T=65 - 75°C; 3 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/71743 A1, 2007 ;
Location in patent: Page/Page column 16 ;
反应条件
1: With sodium methylate in ethanol
T=70 - 75°C; 3 h;
2: With sodium hydroxide in water
pH=11;
3: With hydrogenchloride in water
pH=5.5; Product distribution / selectivity;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/71742 A1, 2007 ;
Location in patent: Page/Page column 19 ;
反应条件
1: With sodium ethanolate in ethanol
T=65 - 75°C; 3 h;
2: With sodium hydroxide in water
pH=11;
3: With hydrogenchloride in water
pH=2 - 4; Product distribution / selectivity;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/71742 A1, 2007 ;
Location in patent: Page/Page column 20 ;
反应条件
1: 4-amino-benzamide oxime With sodium methylate in ethanol
T=70 - 75°C; 0.25 h;
2: carbonic acid diethyl ester in ethanol
T=40°C; 3 h;
3: With hydrogenchloride; sodium hydroxide
more than 3 stages;
参考文献
Boehringer Ingelheim Pharma GmbH and Co.KG
Patent: EP1609784 A1, 2005 ;
Location in patent: Page/Page column 9 ;
