5,6-二氢-3-羟基-4H-吡咯并[1,2-c][1,2,3]恶二唑-7-鎓内盐合成路线 （共 2 条）
反应条件
1: With potassium hydroxide in ethanol T=10 - 26°C; 4.2 - 5.5 h; 2: With hydrogenchloride in water pH=2;
参考文献
Wyeth Holdings Corporation
Patent: US2004/242874 A1, 2004 ;
Location in patent: Page 14-15 ;
反应条件
1: With water; potassium hydroxide
T=80°C; 3 h;
2: With hydrogenchloride in water
参考文献
F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BAKER-GLENN, Charles; CHAN, Bryan K.; DOTSON, Jennafer; ESTRADA, Anthony; HEFFRON, Timothy; LYSSIKATOS, Joseph; SWEENEY, Zachary Kevin
Patent: WO2013/164323 A1, 2013 ;
Location in patent: Page/Page column 51 ;
