1-(5-溴-2,4-二氟苯基)乙酮合成路线 （共 3 条）
反应条件
1: With AlCl3, aluminium chloride T=60 - 95°C; Friedel Crafts Acylation; 10 h; 2: T=-10°C; 1 h;
参考文献
JANSSEN PHARMACEUTICALS, INC.; Cid-Núñez, José Maria; Trabanco-Suárez, Andrés Avelino; Vega Ramiro, Juan Antonio; Oehlrich, Daniel; Tresadern, Gary John; Macdonald, Gregor James
Patent: US2013/252952 A1, 2013 ;
Location in patent: Paragraph 0167; 0168 ;
反应条件
n-butyllithium in diethyl ether; hexane T=-78°C; 0.5 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/85227 A1, 2005 ;
Location in patent: Page/Page column 114-115 ;
WO 2005/085227 A1
反应条件
hydrazine hydrate in water; ethylene glycol T=100 - 150°C; 22 h;
参考文献
WO2012/95781 A1, ;
Page/Page column 114-115 ;
WO 2012/095781 A1
