2-(2,4-二氯-5-氟苯甲酰基)-3-乙氧基丙烯酸乙酯合成路线 （共 19 条）
反应条件
1: 92 percent / ethanol / 1 h / Ambient temperature 2: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 3: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating 4: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: CH2Cl2 / 0.5 h / Ambient temperature 2: NaH / 1,2-dimethoxy-ethane / 3 h / 80 °C 3: aq. NaOH / tetrahydrofuran / 1.5 h / 80 °C View Scheme
参考文献
Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Claiborne, Akiyo K.; Pihuleac, Eva; Nordeen, Carl W.; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1558 - 1564
反应条件
1: in dichloromethane T=10 - 20°C; 1 h; 2: With sodium hydride in ethylene glycol dimethyl ether; mineral oil T=80 - 85°C; 3 h; Inert atmosphere; 3: With water; sodium hydroxide in tetrahydrofuran 2 h; Reflux;
参考文献
Vymed Corporation; SHETTY, B. Vithal
Patent: US2014/73631 A1, 2014 ;
Location in patent: Paragraph 0120; 0124; 0125 ;
反应条件
1: 92 percent / ethanol / 1 h / Ambient temperature 2: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 3: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: 92 percent / ethanol / 1 h / Ambient temperature 2: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 3: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating 4: 79 percent / pyridine / 8 h / Heating 5: 98 percent / conc. HCl / H2O / Heating View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: CH2Cl2 / 0.5 h / Ambient temperature 2: NaH / 1,2-dimethoxy-ethane / 3 h / 80 °C 3: aq. NaOH / tetrahydrofuran / 1.5 h / 80 °C 4: 21.3 g / various solvent(s) / 24 h / 110 °C View Scheme
参考文献
Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Claiborne, Akiyo K.; Pihuleac, Eva; Nordeen, Carl W.; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1558 - 1564
反应条件
1: CH2Cl2 / 0.5 h / Ambient temperature 2: NaH / 1,2-dimethoxy-ethane / 3 h / 80 °C 3: aq. NaOH / tetrahydrofuran / 1.5 h / 80 °C 4: 5.64 g / various solvent(s) / 24 h / 115 °C 5: 5percent NaOH / ethanol / 4 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 11 p. 1558 - 1564
反应条件
1: 92 percent / ethanol / 1 h / Ambient temperature 2: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 3: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating 4: 79 percent / pyridine / 8 h / Heating View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: ethanol / Ambient temperature 2: NaH / dioxane / 1.) r.t., 30 min, 2.) reflux, 2.5 h 3: KOH / H2O / 1.5 h / Heating 4: 69 percent / pyridine / 18 h / Heating View Scheme
参考文献
Bouzard, D.; Cesare, P. Di; Essiz, M.; Jacquet, J. P.; Remuzon, P.; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 537 - 542
反应条件
acetic anhydride
2 h; Heating;
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
