2-(2,4-二氯-5-氟苯甲酰基)-3-乙氧基丙烯酸乙酯合成路线 （共 19 条）
反应条件
1: 80 percent / NaH / 1.5 h / 80 °C
2: Ac2O / 2 h / 130 °C
View Scheme
参考文献
Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Claiborne, Akiyo K.; Pihuleac, Eva; Nordeen, Carl W.; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1558 - 1564
反应条件
1: Mg/ethanol, CCl4 / ethanol; toluene / 1.) 0 to -5 deg C, 2.) 12 h, room temperature
2: p-toluenesulfonic acid / H2O / 5 h / Heating
3: acetic anhydride / 2 h / Heating
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: p-toluenesulfonic acid / H2O / 5 h / Heating
2: acetic anhydride / 2 h / Heating
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: AlCl3, aluminium chloride / 25 h / 70 - 120 °C
2: sodium hydride / tetrahydrofuran / 5 h / 45 - 55 °C / |Inert atmosphere
3: acetic anhydride / 6 h / |Reflux; |Inert atmosphere
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参考文献
Vymed Corporation; SHETTY, B. Vithal
Patent: US2014/73631 A1, 2014 ;
反应条件
in ethanol
1 h; Ambient temperature;
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: 92 percent / ethanol / 1 h / Ambient temperature
2: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: 88 percent / ethanol / 1 h / Ambient temperature
2: 84 percent / 80percent NaH / dioxane / 1. 10 min., room temp. 2. 2.5 h, reflux
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 871 - 880
反应条件
1: 88 percent / ethanol / 1 h / Ambient temperature
2: 84 percent / 80percent NaH / dioxane / 1. 10 min., room temp. 2. 2.5 h, reflux
3: 85 percent / KOH / H2O / 1 h / Heating
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 871 - 880
反应条件
1: 88 percent / ethanol / 1 h / Ambient temperature
2: 84 percent / 80percent NaH / dioxane / 1. 10 min., room temp. 2. 2.5 h, reflux
3: 85 percent / KOH / H2O / 1 h / Heating
4: 72 percent / dimethylsulfoxide / 2.5 h / 140 °C
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 871 - 880
