7-氯-1-环丙基-6-氟-4-氧代-1,4-二氢-喹啉-3-羧酸乙基酯合成路线 （共 16 条）
反应条件
1: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating 2: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
sulfuric acid in water 1.5 h; Heating;
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1.1: 88 percent / Na2CO3 / H2O / 0.17 h / microwave irradiation 2.1: 0.33 h / microwave irradiation 2.2: 78 percent / HCl / H2O / pH 7 View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating 2: 79 percent / pyridine / 8 h / Heating View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
sodium carbonate in dimethyl sulfoxide
0.0666667 h; microwave irradiation;
参考文献
Heravi, Majid M.; Oskooie, Hossein A.; Motamedi, Radineh; Ghassemzadeh, Mitra
Heterocyclic Communications, 2005 , vol. 11, # 5 p. 423 - 426
反应条件
potassium carbonate; acetic acid; triethylamine in water; chlorobenzene; isopropyl alcohol
参考文献
Bayer Aktiengesellschaft
Patent: US6229017 B1, 2001 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=140 - 150°C; 2 h;
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=70°C;
参考文献
Taylor, Rivka R.R.; Twin, Heather C.; Wen, Wendy W.; Mallot, Rebecca J.; Lough, Alan J.; Gray-Owen, Scott D.; Batey, Robert A.
Tetrahedron, 2010 , vol. 66, # 18 p. 3370 - 3377
反应条件
1: 80 percent / H2 / 5percent Pd on charcoal / ethanol / Ambient temperature
2: 1.) conc. HCl, NaNO2; 2.) Cu2Cl2, conc. HCl / 1.) -6 deg C - 7 deg C; 2.) room temp., 1 h.
View Scheme
参考文献
Egawa; Kataoka; Shibamori; et al.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 1 p. 181 - 185
反应条件
PPA
T=70 - 80°C; 2 h;
参考文献
Arava, Veera Reddy; Bandatmakuru, Sreenivasula Reddy
Synthesis (Germany), 2013 , vol. 45, # 8 art. no. SS-2013-Z0041-OP, p. 1039 - 1044
