7-氯-1-环丙基-6-氟-4-氧代-1,4-二氢-喹啉-3-羧酸乙基酯合成路线 （共 16 条）
反应条件
1: acetic anhydride / 2 h / Heating
2: 92 percent / ethanol / 1 h / Ambient temperature
3: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: Mg/ethanol, CCl4 / ethanol; toluene / 1.) 0 to -5 deg C, 2.) 12 h, room temperature
2: p-toluenesulfonic acid / H2O / 5 h / Heating
3: acetic anhydride / 2 h / Heating
4: 92 percent / ethanol / 1 h / Ambient temperature
5: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: p-toluenesulfonic acid / H2O / 5 h / Heating
2: acetic anhydride / 2 h / Heating
3: 92 percent / ethanol / 1 h / Ambient temperature
4: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: 92 percent / ethanol / 1 h / Ambient temperature
2: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
Cu2Cl2; hydrogenchloride; sodium nitrite
1.) -6 deg C - 7 deg C; 2.) room temp., 1 h.; Yield given. Multistep reaction;
参考文献
Egawa; Kataoka; Shibamori; et al.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 1 p. 181 - 185
反应条件
1: potassium hydroxide / |Heating
2: PPA / 2 h / 70 - 80 °C
View Scheme
参考文献
Arava, Veera Reddy; Bandatmakuru, Sreenivasula Reddy
Synthesis (Germany), 2013 , vol. 45, # 8 art. no. SS-2013-Z0041-OP, p. 1039 - 1044
