反应条件
1: sulfuric acid / 12 h / |Reflux; |Inert atmosphere
2: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane / 12 h / 68 °C / |Inert atmosphere
3: potassium carbonate / acetonitrile / 12 h / |Inert atmosphere; |Reflux
View Scheme
参考文献
Sidique, Shyama; Dhanya, Raveendra-Panickar; Sheffler, Douglas J.; Nickols, Hilary Highfield; Yang, Li; Dahl, Russell; Mangravita-Novo, Arianna; Smith, Layton H.; D'Souza, Manoranjan S.; Semenova, Svetlana; Conn, P. Jeffrey; Markou, Athina; Cosford, Nicholas D.P.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9434 - 9445
