(S)-3-氨基-2,3,4,5-四氢-2-氧代-1H-1-苯并氮杂卓-1-乙酸乙酯合成路线 （共 4 条）
反应条件
1: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature 2: 25 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature 3: 69 percent / aq. NaOH / methanol / 18 h / Ambient temperature View Scheme
参考文献
Watthey; Stanton; Desai; Babiarz; Finn
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1511 - 1516
反应条件
1: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature 2: 12 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature View Scheme
参考文献
Watthey; Stanton; Desai; Babiarz; Finn
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1511 - 1516
反应条件
triethylamine in N-methyl-acetamide; ethyl acetate
参考文献
Ciba-Geigy Corporation
Patent: US4473575 A1, 1984 ;
反应条件
1: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature
2: 25 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature
View Scheme
参考文献
Watthey; Stanton; Desai; Babiarz; Finn
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1511 - 1516
