2-氨基-6-氟苯甲酸甲酯合成路线 （共 8 条）
反应条件
in ethanol; ethyl acetate T=20°C; 1.5 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/37796 A1, 2005 ;
Location in patent: Page/Page column 131 ;
反应条件
iron; acetic acid in ethanol T=20°C; 2 h; Heating / reflux;
参考文献
US2006/94707 A1, ;
Page/Page column 66 ;
US 20060094707 A1
反应条件
4-(N,N-dimethlyamino)pyridine 24 h; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH
Patent: WO2009/62289 A1, 2009 ;
Location in patent: Page/Page column 121; 122 ;
反应条件
1: With hydrogenchloride in 1,4-dioxane T=20°C; 0.166667 h; 2: With thionyl chloride in 1,4-dioxane 3 h; Heating / reflux; 3: With sodium hydrogencarbonate in 1,4-dioxane; water
参考文献
Boehringer Ingelheim International GmbH
Patent: EP1598343 A1, 2005 ;
Location in patent: Page/Page column 55 ;
反应条件
hydrogenchloride Pinner reaction;
参考文献
Hamprecht, Gerhard; Wuerzer, Bruno; Witschel, Matthias
Chimia, 2004 , vol. 58, # 3 p. 117 - 122
反应条件
in diethyl ether 1 h; Inert atmosphere;
参考文献
Levesque, Patrick; Fournier, Pierre-Andre
Journal of Organic Chemistry, 2010 , vol. 75, # 20 p. 7033 - 7036
反应条件
1: KF; 18-crown-6 / 3 h / 180 °C 2: NH3 / 10 h / 100 °C 3: 91 percent / HCl View Scheme
参考文献
Chimia, , vol. 58, # 3 p. 117 - 122
反应条件
1: NH3 / 10 h / 100 °C 2: 91 percent / HCl View Scheme
参考文献
Chimia, , vol. 58, # 3 p. 117 - 122
