2,6-二甲基-4-苄氧基苯硼酸合成路线 （共 3 条）
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1.5 h;
2: With tri-isopropoxy-borane in tetrahydrofuran; hexane
T=20°C;
3: With hydrogenchloride in tetrahydrofuran; hexane; water
2.5 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1726580 A1, 2006 ;
Location in patent: Page/Page column 117 ;
EP 1726580 A1
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C
2.1: n-butyllithium / tetrahydrofuran / 4 h / -78 °C / |Inert atmosphere
2.2: 12 h / 20 °C
2.3: 0.5 h
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ECKHARDT, Matthias; FRATTINI, Sara; HAMPRECHT, Dieter; HIMMELSBACH, Frank; LANGKOPF, Elke; LINGARD, Iain; PETERS, Stefan; WAGNER, Holger
Patent: WO2013/144098 A1, 2013 ;
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C
2.1: n-butyllithium / tetrahydrofuran / 4 h / -78 °C / |Inert atmosphere
2.2: 12 h / 20 °C
2.3: 0.5 h
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ECKHARDT, Matthias; FRATTINI, Sara; HAMPRECHT, Dieter; HIMMELSBACH, Frank; LANGKOPF, Elke; LINGARD, Iain; PETERS, Stefan; WAGNER, Holger
Patent: WO2013/144098 A1, 2013 ;
