1: 1.) aq. NaOH; 2.) aq. HCl / 1.) MeOH, room temp., 90 min; 2.) 0 deg C, 3 h, pH=2 2: 96 percent / cc. HBr / 22 h / 100 °C 3: 84 percent / HCl / 4 h / 0 °C 4: 85 percent / NaBH4 / methanol; tetrahydrofuran / 2 h / 25 °C View Scheme