2-[2-(2-叠氮基乙氧基)乙氧基]乙醇合成路线 （共 21 条）
反应条件
boron trifluoride diethyl etherate in dichloromethane 6 h; Ambient temperature;
参考文献
Roy, Rene; Saha, Uttam K.
Chemical Communications, 1996 , # 2 p. 201 - 202
反应条件
sodium azide in N,N-dimethyl-formamide
T=110°C; 3 h; Inert atmosphere;
参考文献
Uppal, Timsy; Bhupathiraju, N.V.S. Dinesh K.; Vicente, M. Graca H.
Tetrahedron, 2013 , vol. 69, # 23 p. 4687 - 4693
反应条件
sodium azide in N,N-dimethyl-formamide
T=0 - 100°C;
参考文献
Lam, Son N.; Acharya, Priyamvada; Wyatt, Richard; Kwong, Peter D.; Bewley, Carole A.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 23 p. 10113 - 10120
反应条件
sodium azide in N,N-dimethyl-formamide
T=20°C;
参考文献
Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard
Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48
反应条件
1: 73 percent / NaH / dimethylformamide / 15 h / 20 °C
2: 99 percent / NaN3 / dimethylformamide; H2O / 17 h / 58 °C
View Scheme
参考文献
Canaria, Christie A.; Smith, Jeffrey O.; Yu; Fraser, Scott E.; Lansford, Rusty
Tetrahedron Letters, 2005 , vol. 46, # 28 p. 4813 - 4816
反应条件
in N-methyl-acetamide; dichloromethane
参考文献
Novo Nordisk A/S
Patent: US2009/36353 A1, 2009 ;
反应条件
1: 5.84 g / Et3N / CH2Cl2 / 0 - 20 °C
2: 84 percent / NaN3 / acetonitrile / 36 h / Heating
3: TsOH; methanol / 4 h / Heating
View Scheme
参考文献
Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte
Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
反应条件
1: 84 percent / NaN3 / acetonitrile / 36 h / Heating
2: TsOH; methanol / 4 h / Heating
View Scheme
参考文献
Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte
Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
反应条件
1: 97 percent / Et3N / CH2Cl2 / 2 h / -78 °C
2: 1.) NaN3, 2.) aq. NH4OH / 1.) EtOH, H2O, 80 deg C, 3 h, 2.) CH3OH, 12 h
View Scheme
参考文献
Hashimoto, Masaru; Liu, Ying; Fang, Kan; Li, Hong-Yu; Campiani, Giuseppe; Nakanishi, Koji
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 6 p. 1181 - 1194
反应条件
methanol; toluene-4-sulfonic acid
4 h; Heating;
参考文献
Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte
Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
