4-乙炔-2,6-二甲基吡啶合成路线 （共 5 条）
反应条件
1: With potassium hydroxide in toluene
1 h; Inert atmosphereReflux;
2: With water in ethyl acetate; toluene
T=20°C; Inert atmosphere;
参考文献
Malamas, Michael S.; Barnes, Keith; Johnson, Matthew; Hui, Yu; Zhou, Ping; Turner, Jim; Hu, Yun; Wagner, Erik; Fan, Kristi; Chopra, Rajiv; Olland, Andrea; Bard, Jonathan; Pangalos, Menelas; Reinhart, Peter; Robichaud, Albert J.
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 2 p. 630 - 639
反应条件
potassium carbonate in methanol
2 h;
参考文献
Winkelhaus, Daniel; Neumann, Beate; Stammler, Hans-Georg; Mitzel, Norbert W.
Dalton Transactions, 2012 , vol. 41, # 30 p. 9143 - 9150
反应条件
1: 84 percent / bis<triphenylphosphine>palladium dichloride, copper(I) iodide, triethylamine / 5 h / 80 °C
2: 62 percent / aq. KOH / methanol / 1 h / Ambient temperature
View Scheme
参考文献
Sakamoto, Takao; Shiraiwa, Masafumi; Kondo, Yoshinori; Yamanaka, Hiroshi
Synthesis, 1983 , # 4 p. 312 - 314
反应条件
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 3 h / 75 °C / Inert atmosphere
2: potassium carbonate / methanol / 2 h
View Scheme
参考文献
Winkelhaus, Daniel; Neumann, Beate; Stammler, Hans-Georg; Mitzel, Norbert W.
Dalton Transactions, 2012 , vol. 41, # 30 p. 9143 - 9150
反应条件
sulfuric acid; water; mercuric sulphate in acetone
2 h; Heating;
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Shiraiwa, Masafumi; Yamanaka, Hiroshi
Synthesis, 1984 , # 3 p. 245 - 247
