2-(2-(三甲基甲硅烷基)乙炔)喹啉合成路线 （共 7 条）
反应条件
1: quinolinyl-N-oxide With isobutyl chloroformate in tetrahydrofuran
T=-78 - 20°C;
2: Me3SiC≡CMgBr in tetrahydrofuran
T=-78 - 20°C; 2 h;
3: With water in tetrahydrofuran
T=20°C;
参考文献
Fakhfakh, Mohamed; Figadere, Bruno; Fournet, Alain; Franck, Xavier; Hocquemiller, Reynald; Prina, Eric
Patent: US2005/165052 A1, 2005 ;
Location in patent: Page/Page column 4 ;
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine
T=60°C; Sonogashira Cross-Coupling; 3 h; Inert atmosphere;
参考文献
Son, Myung-Hee; Kim, Ji Young; Lim, Eun Jeong; Baek, Du-Jong; Choi, Kihang; Lee, Jae Kyun; Pae, Ae Nim; Min, Sun-Joon; Cho, Yong Seo
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1472 - 1476
反应条件
N-ethyl-N,N-diisopropylamine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tris-(o-tolyl)phosphine in tetrahydrofuran
1 h; Ambient temperature;
参考文献
Okita, Takaaki; Isobe, Minoru
Tetrahedron, 1995 , vol. 51, # 13 p. 3737 - 3744
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine
T=70°C; 3 h;
参考文献
Sakamoto, Takao; Shiraiwa, Masafumi; Kondo, Yoshinori; Yamanaka, Hiroshi
Synthesis, 1983 , # 4 p. 312 - 314
反应条件
in tetrahydrofuran
T=-78°C;
参考文献
Fakhfakh, Mohamed A.; Franck, Xavier; Fournet, Alain; Hocquemiller, Reynald; Figadere, Bruno
Tetrahedron Letters, 2001 , vol. 42, # 23 p. 3847 - 3850
反应条件
1: tetrahydrofuran
2: tetrahydrofuran / -78 °C
View Scheme
参考文献
Fakhfakh, Mohammed A.; Fournet, Alain; Prina, Eric; Mouscadet, Jean-Francois; Franck, Xavier; Hocquemiller, Reynald; Figadere, Bruno
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5013 - 5023
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
参考文献
Fakhfakh, Mohamed; Figadere, Bruno; Fournet, Alain; Franck, Xavier; Hocquemiller, Reynald; Prina, Eric
Patent: US2005/165052 A1, 2005 ;
Location in patent: Page/Page column 5 ;
