5-(2-异丙基-4-甲氧基苯氧基)嘧啶-2,4-二胺合成路线 （共 5 条）
反应条件
in N,N-dimethyl-formamide
T=120°C; 72 h;
参考文献
Roche Palo Alto LLC
Patent: US2008/86004 A1, 2008 ;
Location in patent: Page/Page column 15 ;
反应条件
in N,N-dimethyl-formamide
T=120°C; 72 h;
参考文献
Roche Palo Alto LLC
Patent: US2007/49758 A1, 2007 ;
Location in patent: Page/Page column 31 ;
US 20070049758 A1
反应条件
in N,N-dimethyl-formamide
T=120°C; 72 h;
参考文献
Roche Palo Alto LLC
Patent: US2007/49534 A1, 2007 ;
Location in patent: Page/Page column 32-33 ;
US 20070049534 A1
反应条件
sodium methylate in dimethyl sulfoxide
T=110°C;
参考文献
Carter, David S.; Alam, Muzaffar; Cai, Haiying; Dillon, Michael P.; Ford, Anthony P.D.W.; Gever, Joel R.; Jahangir, Alam; Lin, Clara; Moore, Amy G.; Wagner, Paul J.; Zhai, Yansheng
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 6 p. 1628 - 1631
反应条件
iodine cloride in water; acetic acid
17 h;
参考文献
Roche Palo Alto LLC
Patent: US2007/49609 A1, 2007 ;
Location in patent: Page/Page column 87-88 ;
US 20070049609 A1
