5-(5-碘-2-异丙基-4-甲氧基苯氧基)嘧啶-2,4-二胺合成路线 （共 4 条）
反应条件
iodine cloride in water; acetic acid
17 h;
参考文献
Roche Palo Alto LLC
Patent: US2007/49609 A1, 2007 ;
Location in patent: Page/Page column 87-88 ;
US 20070049609 A1
反应条件
in N,N-dimethyl-formamide
T=120°C; 18 h; Product distribution / selectivity;
参考文献
Constantinescu, Anton; Green, Keena Lynn; Humphreys, Eric Roy; Lee, Gary R.; McGarry, Patrick Finbar
Patent: US2007/49751 A1, 2007 ;
Location in patent: Page/Page column 21; 23-24 ;
US 20070049751 A1
反应条件
sodium methylate in dimethyl sulfoxide
T=110°C;
参考文献
Carter, David S.; Alam, Muzaffar; Cai, Haiying; Dillon, Michael P.; Ford, Anthony P.D.W.; Gever, Joel R.; Jahangir, Alam; Lin, Clara; Moore, Amy G.; Wagner, Paul J.; Zhai, Yansheng
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 6 p. 1628 - 1631
反应条件
1: With boron tribromide in dichloromethane
T=0 - 20°C; 16 h;
2: With water in dichloromethane
参考文献
Roche Palo Alto LLC
Patent: US2007/49609 A1, 2007 ;
Location in patent: Page/Page column 105-106 ;
US 20070049609 A1
