2-(叔丁氧基羰基氨基)-2-氰基乙酸乙酯合成路线 （共 6 条）
反应条件
N-ethyl-N,N-diisopropylamine in toluene
T=100°C; 5 h;
参考文献
Poulsen, Thomas B.; Dickmeiss, Gustav; Overgaard, Jacob; Jorgensen, Karl Anker
Angewandte Chemie - International Edition, 2008 , vol. 47, # 25 p. 4687 - 4690
反应条件
1: cyanoacetic acid ethyl ester With lithium hexamethyldisilazane in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: oxaziridine-2,3,3-tricarboxylic acid 2-tert-butyl ester 3,3-diethyl ester in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Armstrong, Alan; Edmonds, Ian D.; Swarbrick, Martin E.; Treweeke, Nigel R.
Tetrahedron, 2005 , vol. 61, # 35 p. 8423 - 8442
参考文献
He, Xinhua; Wang, Lili; Zheng, Zhibing; Xiao, Junhai; Zhong, Wu; Li, Song
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 553 - 557
反应条件
1: cyanoacetic acid ethyl ester With lithium hexamethyldisilazane in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: oxaziridine-2,3,3-tricarboxylic acid 2-tert-butyl ester 3,3-diethyl ester in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Armstrong, Alan; Edmonds, Ian D.; Swarbrick, Martin E.; Treweeke, Nigel R.
Tetrahedron, 2005 , vol. 61, # 35 p. 8423 - 8442
反应条件
1: sodium dithionite; sodium hydrogencarbonate / water / 1 h / 35 °C
2: N-ethyl-N,N-diisopropylamine / toluene / 5 h / 100 °C
View Scheme
参考文献
Breistein, Palle; Johansson, Jonas; Ibrahem, Ismail; Lin, Shuangzheng; Deiana, Luca; Sun, Junliang; Cordova, Armando
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 6 p. 1156 - 1162
反应条件
1: hydrogenchloride; sodium nitrite
2: acetic acid; zinc
View Scheme
参考文献
He, Xinhua; Wang, Lili; Zheng, Zhibing; Xiao, Junhai; Zhong, Wu; Li, Song
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 553 - 557
