1,1,1-三氟-4-苯基-2-丁酮合成路线 （共 31 条）
反应条件
1: 38 percent / oxone; NaHCO3; aq. Na2*EDTA / acetonitrile / 2 h / 20 °C 2: aq. KOH / 19 h / Heating View Scheme
参考文献
Yang, Dan; Wong, Man-Kin; Yan, Zheng
Journal of Organic Chemistry, 2000 , vol. 65, # 13 p. 4179 - 4184
反应条件
1: selenium(IV) oxide / tert-butyl alcohol / 72 h / 85 °C 2: potassium hydroxide; water / ethanol / 2 h / 0 - 20 °C View Scheme
参考文献
Li, Qingjiang; Tochtrop, Gregory P.
Organic Letters, 2014 , vol. 16, # 5 p. 1382 - 1385
反应条件
hydrogen; palladium on activated charcoal in methanol
T=20°C; P=1520 Torr; 2 h;
参考文献
Sterk, Damjan; Stephan, Michel; Mohar, Barbara
Organic Letters, 2006 , vol. 8, # 26 p. 5935 - 5938
反应条件
Oxonereg;; sodium 2-iodobenzenesulfonate in nitromethane
T=110°C; 24 h;
参考文献
Tanaka, Yusuke; Ishihara, Takashi; Konno, Tsutomu
Journal of Fluorine Chemistry, 2012 , vol. 137, p. 99 - 104
反应条件
in diethyl ether
T=-78 - 20°C; Grignard reaction;
参考文献
Ichikawa, Junji; Yokota, Misaki; Kudo, Takao; Umezaki, Satoshi
Angewandte Chemie - International Edition, 2008 , vol. 47, # 26 p. 4870 - 4873
反应条件
Triethylgermyl-natrium in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=-60°C; 1.5 h;
参考文献
Yokoyama, Yasuo; Mochida, Kunio
Synlett, 1997 , vol. 1997, # 8 p. 907 - 908
反应条件
1: 2-(phenyl)ethyl bromide With magnesium in diethyl ether
Inert atmosphere;
2: ethyl-α,α,α-trifluoroacetate in diethyl ether
T=-78 - 20°C;
参考文献
Fuchibe, Kohei; Jyono, Hideharu; Fujiwara, Masaki; Kudo, Takao; Yokota, Misaki; Ichikawa, Junji
Chemistry - A European Journal, 2011 , vol. 17, # 43 p. 12175 - 12185
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
12 h;
参考文献
Gorbunova, M. G.; Gerus, I. I.; Kukhar, V. P.
Journal of Fluorine Chemistry, 1993 , vol. 65, # 1-2 p. 25 - 28
反应条件
baker's yeast in water
T=35 - 37°C; 240 h;
参考文献
Kitazume, Tomoya; Ishikawa, Nobuo
Chemistry Letters, 1984 , p. 587 - 590
反应条件
pyridine in dichloromethane
T=-10°C; Substitution; 4 h;
参考文献
Yang, Dan; Wong, Man-Kin; Yan, Zheng
Journal of Organic Chemistry, 2000 , vol. 65, # 13 p. 4179 - 4184
