1,1,1-三氟-4-苯基-2-丁酮合成路线 （共 31 条）
反应条件
1: With tetra-n-butylammonium acetate in toluene
T=0 - 20°C; 1 h;
2: With hydrogenchloride in tetrahydrofuran; toluene
参考文献
Kawano, Yoshikazu; Kaneko, Nobuya; Mukaiyama, Teruaki
Bulletin of the Chemical Society of Japan, 2006 , vol. 79, # 7 p. 1133 - 1145
反应条件
1: CsF / neat (no solvent) / 4 h / 25 °C
2: HCl / H2O / 3 h
View Scheme
参考文献
Singh, Rajendra P.; Cao, Ganfeng; Kirchmeier, Robert L.; Shreeve, Jean'ne M.
Journal of Organic Chemistry, 1999 , vol. 64, # 8 p. 2873 - 2876
反应条件
1: 97 percent / tetrahydrofuran / 1 h / -78 °C
2: 100 percent / KOH / ethanol / 20 °C
3: 95 percent / Co(III) o-phenylene-bis(N'-methyloxamidate) complex; O2; pivalaldehyde / CH2Cl2
View Scheme
参考文献
Blay, Gonzalo; Fernandez, Isabel; Marco-Aleixandre, Alicia; Monje, Belen; Pedro, Jose R; Ruiz, Rafael
Tetrahedron, 2002 , vol. 58, # 42 p. 8565 - 8571
反应条件
1: 100 percent / KOH / ethanol / 20 °C
2: 95 percent / Co(III) o-phenylene-bis(N'-methyloxamidate) complex; O2; pivalaldehyde / CH2Cl2
View Scheme
参考文献
Blay, Gonzalo; Fernandez, Isabel; Marco-Aleixandre, Alicia; Monje, Belen; Pedro, Jose R; Ruiz, Rafael
Tetrahedron, 2002 , vol. 58, # 42 p. 8565 - 8571
反应条件
in water
T=35 - 36°C; 240 h; backer's yeast in Na2PO4, KH2PO4 buffer (pH = 7.3); Yields of byproduct given;
参考文献
Kitazume,T.; Ishikawa,N.
Journal of Fluorine Chemistry, 1985 , vol. 29, p. 431
反应条件
1: 80 percent / 1M LDA; HMPT / tetrahydrofuran / 1.) 2 h; 2.) 2 h; 3.) 22 h, RT
2: 90 percent / EtBr / aq. ethanol / 48 h / Heating
3: 85 percent / LiCl, H2O / dimethylformamide / 2 h / Heating
View Scheme
参考文献
Aubert, Corinne; Begue, Jean-Pierre; Charpentier-Morize, Micheline; Nee, Gerard; Langlois, Bernard
Journal of Fluorine Chemistry, 1989 , vol. 44, p. 377 - 394
反应条件
sodium methylate in tetrahydrofuran
4 h; RefluxInert atmosphere; Reagent/catalyst;
参考文献
Yang, Dongmei; Zhou, Yuhan; Xue, Na; Qu, Jingping
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 4171 - 4176
反应条件
potassium dihydrogenphosphate; sodium dihydrogenphosphate; starch
T=35 - 36°C; 120 h; pH 7.3; stereoselective reduction of triple bond with baker's yeast; Product distribution;
参考文献
Kitazume,T.; Sato,T.
Journal of Fluorine Chemistry, 1985 , vol. 30, p. 189
反应条件
in tetrahydrofuran
0.5 h; Heating;
参考文献
Kimura, Mitsuo; Yamazaki, Takashi; Kitazume, Tomoya; Kubota, Toshio
Organic Letters, 2004 , vol. 6, # 25 p. 4651 - 4654
反应条件
1: 87 percent / tetrahydrofuran / 0.5 h / Heating
2: (R)-(+)-binaphthol; LiAlH4 / ethanol; tetrahydrofuran / 24 h / -78 °C
3: Et3N; DMAP / CH2Cl2 / 0 - 20 °C
4: CuCN; TMSCl / diethyl ether / 0 °C
View Scheme
参考文献
Kimura, Mitsuo; Yamazaki, Takashi; Kitazume, Tomoya; Kubota, Toshio
Organic Letters, 2004 , vol. 6, # 25 p. 4651 - 4654
