1.1: 55 percent / aq. sodium benzoate / 12 h / 130 °C 2.1: NaH / dimethylformamide / 0.5 h / 0 °C 2.2: 94 percent / dimethylformamide / 2 h 3.1: BH3*THF / tetrahydrofuran / 3 h / 0 °C 3.2: 31 percent / aq. NaOH; aq. H2O2 / tetrahydrofuran / 3 h / 25 °C 4.1: 93 percent / PPh3; DEAD / tetrahydrofuran / 12 h / 25 °C 5.1: 91 percent / PdCl2; H2 / ethyl acetate; methanol / 4 h / 25 °C / 760 Torr View Scheme