(S)-莫达非尼羧酸酯甲酯合成路线 （共 7 条）
反应条件
potassium carbonate in acetone Reflux;
参考文献
Cao, Jianjing; Prisinzano, Thomas E.; Okunola, Oluyomi M.; Kopajtic, Theresa; Shook, Matthew; Katz, Jonathan L.; Newman, Amy Hauck
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 48 - 52
反应条件
1-n-butyl-3-methylimidazolium hexafluorophosphate in tetrachloromethane T=20°C; 48 h; Title compound not separated from byproducts.;
参考文献
Tetrahedron Asymmetry, , vol. 18, # 24 p. 2959 - 2964
反应条件
1.1: 99 percent / trifluoroacetic acid / 3 h / 20 °C 2.1: 99 percent / H2SO4 / Heating 3.1: H2SO4; 2-propanol; aq. H2O2 / methanol / 20 °C 4.1: 62.1 g / NaOH; H2O / ethanol / 1 h / 20 °C 5.1: (R)-(+)-α-methylbenzylamine / H2O / Heating 5.2: 17.0 g / aq. HCl / pH 2 6.1: 65 percent / K2CO3 / acetone / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 6 p. 1053 - 1058
反应条件
1.1: 99 percent / H2SO4 / Heating 2.1: H2SO4; 2-propanol; aq. H2O2 / methanol / 20 °C 3.1: 62.1 g / NaOH; H2O / ethanol / 1 h / 20 °C 4.1: (R)-(+)-α-methylbenzylamine / H2O / Heating 4.2: 17.0 g / aq. HCl / pH 2 5.1: 65 percent / K2CO3 / acetone / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 6 p. 1053 - 1058
反应条件
1.1: H2SO4; 2-propanol; aq. H2O2 / methanol / 20 °C 2.1: 62.1 g / NaOH; H2O / ethanol / 1 h / 20 °C 3.1: (R)-(+)-α-methylbenzylamine / H2O / Heating 3.2: 17.0 g / aq. HCl / pH 2 4.1: 65 percent / K2CO3 / acetone / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 6 p. 1053 - 1058
反应条件
1.1: (R)-(+)-α-methylbenzylamine / H2O / Heating 1.2: 17.0 g / aq. HCl / pH 2 2.1: 65 percent / K2CO3 / acetone / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 6 p. 1053 - 1058
反应条件
1.1: 62.1 g / NaOH; H2O / ethanol / 1 h / 20 °C 2.1: (R)-(+)-α-methylbenzylamine / H2O / Heating 2.2: 17.0 g / aq. HCl / pH 2 3.1: 65 percent / K2CO3 / acetone / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 6 p. 1053 - 1058
