乙烯基2,2,5-三甲基-1,3-二恶烷-5-羧酸酯合成路线 （共 4 条）
反应条件
1: H2SO4 / acetonitrile; H2O / 4 h / 20 °C 2: 78 percent / 1.5 h / 20 °C 3: 78 percent / Amano I Burkholderia cepacia lipase PC-D; molecular sieves 5 Angstroem / various solvent(s) / 48 h / 40 - 42 °C 4: 78 percent / MeOH / various solvent(s) View Scheme
参考文献
Gu, Jianxin; Ruppen, Mark E.; Cai, Ping
Organic Letters, 2005 , vol. 7, # 18 p. 3945 - 3948
→
162635-03-2(1R,2R,4S)-4-{(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-二羟基-19,30-二甲氧基-15,17,21,23,29,35-六甲基-2,3,10,14,20-五氧代-11,36-二氧杂-4-氮杂三环[30.3.1.04,9]三十六碳-16,24,26,28-四烯-12-基]丙基}-2-甲氧基环己基2,2,5-三甲基-1,3-二恶烷-5-羧酸酯
反应条件
5A molecular sieve; Amano II Burkholderia cepacia lipase PS-C in various solvent(s) T=42 - 43°C; 48 h;
参考文献
Gu, Jianxin; Ruppen, Mark E.; Cai, Ping
Organic Letters, 2005 , vol. 7, # 18 p. 3945 - 3948
反应条件
vinyl acetate; lithium chloride; palladium dichloride in methanol
16 h; Heating / reflux;
参考文献
Wyeth
Patent: US2005/234086 A1, 2005 ;
Location in patent: Page/Page column 13 ;
反应条件
lithium chloride; palladium dichloride
16 h; Heating;
参考文献
Gu, Jianxin; Ruppen, Mark E.; Cai, Ping
Organic Letters, 2005 , vol. 7, # 18 p. 3945 - 3948
