[(1S,3S)-3-[[4-甲氧基-3-(3-甲氧基丙氧基)苯基]甲基]-4-甲基-1-[(2S,4S)-四氢-4-异丙基-5-氧代-2-呋喃基]戊基]-氨基甲酸叔丁酯合成路线 （共 84 条）
反应条件
1: 65 percent / 2-hydroxypyridine; Et3N 2: TMSCl; phenol / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 37 p. 6337 - 6340
反应条件
1: With hydrogen; palladium 10 on activated carbon in methanol
P=760.051 Torr; 12 h;
2: With 1H-imidazole in methanol
Inert atmosphere;
参考文献
Chemo Iberica, S.A.; Taddei, Maurizio; Russo, Adele; Cini, Elena; Riva, Renata; Rasparini, Marcello; Carcone, Luca; Banfi, Luca; Vitale, Romina; Roseblade, Stephen; Zanotti-Gerosa, Antonio Carlo
Patent: US2013/71899 A1, 2013 ;
Location in patent: Paragraph 0211-0212 ;
反应条件
hydrogen; palladium 10 on activated carbon in ethanol; water
T=20°C; 68 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2007/45420 A2, 2007 ;
Location in patent: Page/Page column 72-73 ;
反应条件
hydrogen; palladium 10 on activated carbon in ethanol; acetic acid
T=50°C; P=3750.38 Torr; 46 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2007/45420 A2, 2007 ;
Location in patent: Page/Page column 69-72 ;
反应条件
iron (III) acetylacetonate in tetrahydrofuran
T=-20 - 20°C; Inert atmosphere; Solvent;
参考文献
Zhejiang Tianyu Pharmaceutical Co., Ltd; TU, Yongjun; ZHANG, Yi; CHENG, Rongde; PENG, Lingchao
Patent: EP2546243 A1, 2013 ;
Location in patent: Paragraph 0038; 0039 ;
反应条件
1: 4-bromo-1-methoxy-2-(3-methoxypropoxy)benzene With isopropylmagnesium chloride in tetrahydrofuran
0.25 h; Inert atmosphereCooling with ice;
2: With n-butyllithium in tetrahydrofuran; hexane
4 h; Inert atmosphere;
3: [(1S,3S)-3-bromomethyl-1-((2S,4S)-4-isopropyl-5-oxofuranidin-2-yl)-4-methylpentyl]-carbamic acid tert-butyl ester With iron (III) acetylacetonate in tetrahydrofuran; hexane
T=-20 - 20°C; Inert atmosphere; Solvent;
参考文献
Zhejiang Tianyu Pharmaceutical Co., Ltd.; Tu, Yongjun; Zhang, Yi; Cheng, Rongde; Peng, Lingchao
Patent: US2013/225841 A1, 2013 ;
Location in patent: Paragraph 0037; 0038; 0039 ;
反应条件
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide
参考文献
Dong, Hua; Zhang, Zhi-Liu; Huang, Jia-Hui; Ma, Rujian; Chen, Shu-Hui; Li, Ge
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6337 - 6340
反应条件
palladium 10 on activated carbon; hydrogen; triethylamine in ethyl acetate
T=20°C; 6 h;
参考文献
JUBILANT LIFE SCIENCES LIMITED; BISWAS, Sujay; SRIMURUGAN, Sankareswaran; KUMAR, Anjul; PANDA, Atulya, Kumar; JAMSHAD, Danish; MASAND, Mukesh; BISWAS, Bidyut; BANSAL, Vikas; GUPTA, Ashish, Kumar; VIR, Dharam
Patent: WO2013/61224 A1, 2013 ;
Location in patent: Page/Page column 21 ;
反应条件
hydrogen; palladium 10 on activated carbon in ethanol; water
T=20°C; 68 h;
参考文献
NOVARTIS AG
Patent: WO2008/119804 A1, 2008 ;
Location in patent: Page/Page column 67-68 ;
WO 2008/119804 A1
反应条件
2,2'-azo-bisisobutyronitrile; tris-(trimethylsilyl)silane in tert-dodecanethiol; toluene
T=100°C; 0.25 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2007/45420 A2, 2007 ;
Location in patent: Page/Page column 78 ;
