1.1: sodium iodide / acetonitrile / Inert atmosphere; Reflux 2.1: N,N-dimethyl acetamide / 24 h / 25 °C / Inert atmosphere 3.1: triethylamine / 4-(N,N-dimethlyamino)pyridine / 3 h / Inert atmosphere 4.1: trifluoroacetic acid / 1 h / 20 °C / Inert atmosphere 5.1: triethylamine; hydrogen / [Rh(S)-phanephos(cod)]BF4 / ethanol / 6 h / 60 °C / 22502.3 Torr / Autoclave 6.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 80 °C / Inert atmosphere 6.2: 8 h / 50 °C / Reflux 7.1: hydrogenchloride; water / ethanol / 48 h / 70 °C 8.1: hydrogen / palladium 10 on activated carbon / methanol / 12 h / 760.05 Torr 8.2: Inert atmosphere View Scheme

1.1: N,N-dimethyl acetamide / 24 h / 25 °C / Inert atmosphere 2.1: triethylamine / 4-(N,N-dimethlyamino)pyridine / 3 h / Inert atmosphere 3.1: trifluoroacetic acid / 1 h / 20 °C / Inert atmosphere 4.1: triethylamine; hydrogen / [Rh(S)-phanephos(cod)]BF4 / ethanol / 6 h / 60 °C / 22502.3 Torr / Autoclave 5.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 80 °C / Inert atmosphere 5.2: 8 h / 50 °C / Reflux 6.1: hydrogenchloride; water / ethanol / 48 h / 70 °C 7.1: hydrogen / palladium 10 on activated carbon / methanol / 12 h / 760.05 Torr 7.2: Inert atmosphere View Scheme

1.1: triethylamine / 4-(N,N-dimethlyamino)pyridine / 3 h / Inert atmosphere 2.1: trifluoroacetic acid / 1 h / 20 °C / Inert atmosphere 3.1: triethylamine; hydrogen / [Rh(S)-phanephos(cod)]BF4 / ethanol / 6 h / 60 °C / 22502.3 Torr / Autoclave 4.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 80 °C / Inert atmosphere 4.2: 8 h / 50 °C / Reflux 5.1: hydrogenchloride; water / ethanol / 48 h / 70 °C 6.1: hydrogen / palladium 10 on activated carbon / methanol / 12 h / 760.05 Torr 6.2: Inert atmosphere View Scheme

1.1: trifluoroacetic acid / 1 h / 20 °C / Inert atmosphere 2.1: triethylamine; hydrogen / [Rh(S)-phanephos(cod)]BF4 / ethanol / 6 h / 60 °C / 22502.3 Torr / Autoclave 3.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 80 °C / Inert atmosphere 3.2: 8 h / 50 °C / Reflux 4.1: hydrogenchloride; water / ethanol / 48 h / 70 °C 5.1: hydrogen / palladium 10 on activated carbon / methanol / 12 h / 760.05 Torr 5.2: Inert atmosphere View Scheme

1.1: hydrogenchloride; tri-(hydroxymethyl)-methylamine; water; HLAP / 48 h / 40 °C / Enzymatic reaction 1.2: 20 °C / pH 3.5 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 40 °C / Inert atmosphere 2.2: 20 °C 3.1: triethylamine / toluene / 1.5 h / 0 - 20 °C / Inert atmosphere 4.1: sodium iodide / acetonitrile / Inert atmosphere; Reflux 5.1: N,N-dimethyl acetamide / 24 h / 25 °C / Inert atmosphere 6.1: triethylamine / 4-(N,N-dimethlyamino)pyridine / 3 h / Inert atmosphere 7.1: trifluoroacetic acid / 1 h / 20 °C / Inert atmosphere 8.1: triethylamine; hydrogen / [Rh(S)-phanephos(cod)]BF4 / ethanol / 6 h / 60 °C / 22502.3 Torr / Autoclave 9.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 80 °C / Inert atmosphere 9.2: 8 h / 50 °C / Reflux 10.1: hydrogenchloride; water / ethanol / 48 h / 70 °C 11.1: hydrogen / palladium 10 on activated carbon / methanol / 12 h / 760.05 Torr 11.2: Inert atmosphere View Scheme

1.1: triethylamine / N,N-dimethyl aminopyride / methanol 2.1: sodium methylate / methanol / 0.5 h / 20 °C 2.2: 4 h / 80 °C 2.3: 1 h / 50 °C View Scheme

1.1: triethylamine / N,N-dimethyl aminopyride / methanol / 24 h 2.1: sodium methylate / methanol / 0.5 h / 20 °C 2.2: 4 h / 80 °C 2.3: 1 h / 50 °C View Scheme

1.1: oxalyl dichloride / N,N-dimethyl-formamide / acetonitrile / 4.5 h / 0 - 40 °C / Inert atmosphere 2.1: titanium tetrachloride / dichloromethane / 4 h / 0 - 40 °C / Inert atmosphere 3.1: triethylsilane; titanium tetrachloride / dichloromethane / 0 - 20 °C / Inert atmosphere 3.2: N,N-dimethylaminopyride / 24 h / 20 °C 4.1: sodium methylate / methanol / 0.5 h / 20 °C 4.2: 4 h / 80 °C 4.3: 1 h / 50 °C View Scheme

1: 3-methoxypropan-1-ol With sodium hydride Inert atmosphere; 2: C26H40BrNO5 T=110 - 115°C; 3 h; Autoclave; Product distribution / selectivity;

1: Mg 2: 23 percent / H2 / Pd(OH)2/C 3: 38 percent / TPAP; NMMO View Scheme