[(1S,3S)-3-[[4-甲氧基-3-(3-甲氧基丙氧基)苯基]甲基]-4-甲基-1-[(2S,4S)-四氢-4-异丙基-5-氧代-2-呋喃基]戊基]-氨基甲酸叔丁酯合成路线 （共 84 条）
反应条件
1.1: methanol / 1 h / 20 °C
2.1: triethylsilane / dichloromethane / 20 °C
2.2: -78 - -75 °C
3.1: hydrogenchloride / methanol / 2 h / 50 - 55 °C
3.2: pH 10.5 - 11
4.1: triethylamine / dichloromethane / 3 h / 20 °C
View Scheme
参考文献
JUBILANT LIFE SCIENCES LIMITED; BISWAS, Sujay; SRIMURUGAN, Sankareswaran; KUMAR, Anjul; PANDA, Atulya, Kumar; JAMSHAD, Danish; MASAND, Mukesh; BISWAS, Bidyut; BANSAL, Vikas; GUPTA, Ashish, Kumar; VIR, Dharam
Patent: WO2013/61224 A1, 2013 ;
反应条件
1.1: triethylsilane / dichloromethane / 20 °C
1.2: -78 - -75 °C
2.1: hydrogenchloride / methanol / 2 h / 50 - 55 °C
2.2: pH 10.5 - 11
3.1: triethylamine / dichloromethane / 3 h / 20 °C
View Scheme
参考文献
JUBILANT LIFE SCIENCES LIMITED; BISWAS, Sujay; SRIMURUGAN, Sankareswaran; KUMAR, Anjul; PANDA, Atulya, Kumar; JAMSHAD, Danish; MASAND, Mukesh; BISWAS, Bidyut; BANSAL, Vikas; GUPTA, Ashish, Kumar; VIR, Dharam
Patent: WO2013/61224 A1, 2013 ;
反应条件
1.1: sodium tetrahydroborate; CuSO4‵5H2O; methanol / 0 - 5 °C / Inert atmosphere
1.2: N,N-dimethylaminopyride
2.1: sodium hydride / Inert atmosphere
2.2: 3 h / 110 - 115 °C / Autoclave
View Scheme
参考文献
CARBODESIGN LLC
Patent: US2012/296100 A1, 2012 ;
反应条件
2-ethyl-1-hexanoic acid in n-heptane
T=60°C; Reagent/catalystTemperatureSolventTime;
参考文献
CHEMO IBERICA, S. A.; CARCONE, Luca; MAGRONE, Domenico; BARRECA, Giuseppe; RASPARINI, Marcello; LI MING, Huan
Patent: WO2013/14191 A1, 2013 ;
Location in patent: Page/Page column 11; 12 ;
