4-硝基-2,3,5-三甲基吡啶-N-氧化物合成路线 （共 16 条）
反应条件
1: With acetic anhydride; acetic acid T=90°C; 2 h; 2: With hydrogenchloride 2 h; Further stages.;
参考文献
Synthetic Communications, , vol. 38, # 4 p. 576 - 582
反应条件
2: 110 °C
3: aq. NaOH / methanol / Heating
4: 90 percent / SOCl2 / CH2Cl2 / 0.5 h / Heating
5: 84 percent / aq. NaOH / methanol / Heating
View Scheme
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
sodium methylate in methanol
参考文献
Hoffman-La Roche Inc.
Patent: US4766133 A1, 1988 ;
反应条件
sodium methylate
T=40°C; 16 h;
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
2: 110 °C
View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
