4-甲氧基-2,3,5-三甲基吡啶-n-氧化物合成路线 （共 23 条）
反应条件
in methanol
T=70°C; 16 h;
参考文献
Mittelbach, Martin; Schmidt, Hans-Werner; Uray, Georg; Junek, Hans; Lamm, Bo; et al.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1988 , vol. 42, # 8 p. 524 - 529
反应条件
1: HNO3 / Heating
View Scheme
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
1: 78 percent / hydrogen, conc. H2SO4 / 10percent Pd/C / ethanol / 20 °C / 1500.1 Torr
2: 77 percent / KOH / dimethylsulfoxide / 15 h / 60 °C
3: 95 percent / H2O2 / acetic acid / 30 deg C, 1 h -> 70 deg C, 5 h -> 90 deg C
View Scheme
参考文献
Mittelbach, Martin; Schmidt, Hans-Werner; Uray, Georg; Junek, Hans; Lamm, Bo; et al.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1988 , vol. 42, # 8 p. 524 - 529
反应条件
1: 95 percent / phosphoryl chloride / 4 h / 150 °C
2: 78 percent / hydrogen, conc. H2SO4 / 10percent Pd/C / ethanol / 20 °C / 1500.1 Torr
3: 77 percent / KOH / dimethylsulfoxide / 15 h / 60 °C
4: 95 percent / H2O2 / acetic acid / 30 deg C, 1 h -> 70 deg C, 5 h -> 90 deg C
View Scheme
参考文献
Mittelbach, Martin; Schmidt, Hans-Werner; Uray, Georg; Junek, Hans; Lamm, Bo; et al.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1988 , vol. 42, # 8 p. 524 - 529
反应条件
sodium methylate
T=40°C; 16 h;
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
反应条件
1: 77 percent / KOH / dimethylsulfoxide / 15 h / 60 °C
2: 95 percent / H2O2 / acetic acid / 30 deg C, 1 h -> 70 deg C, 5 h -> 90 deg C
View Scheme
参考文献
Mittelbach, Martin; Schmidt, Hans-Werner; Uray, Georg; Junek, Hans; Lamm, Bo; et al.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1988 , vol. 42, # 8 p. 524 - 529
反应条件
1: 76 percent / 30percent aq. H2O2, HOAc / 23 h / 90 °C
2: HNO3 / Heating
View Scheme
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
参考文献
Sharada; Satyanarayana Reddy; Sammaiah; Sumalatha
Asian Journal of Chemistry, 2013 , vol. 25, # 14 p. 7959 - 7966
反应条件
1: 110 °C
2: aq. NaOH / methanol / Heating
3: 90 percent / SOCl2 / CH2Cl2 / 0.5 h / Heating
4: 84 percent / aq. NaOH / methanol / Heating
View Scheme
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
