(S)-4-(2-(苄氧基羰基)-2-(Cbz-氨基)乙基)苯硼酸合成路线 （共 11 条）
反应条件
1: 207 mg / aq. NaOH / 1 h 2: 63 percent / hydrogen; aq. HCl / Pd(OH)2/C / ethanol / 19 h / 20 °C View Scheme
参考文献
Nakamura, Hiroyuki; Fujiwara, Masaru; Yamamoto, Yoshinori
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 1 p. 231 - 235
参考文献
Skaff, Ojia; Jolliffe, Katrina A.; Hutton, Craig A.
Journal of Organic Chemistry, 2005 , vol. 70, # 18 p. 7353 - 7363
反应条件
1.1: potassium carbonate; tetrabutylammonium iodide / acetone / 0.5 h / 20 °C
1.2: 2.86 g / acetone / 2 h / Heating
2.1: 92 percent / Pd(dppf)Cl2*CH2Cl2; KOAc / dimethylsulfoxide / 4.5 h / 80 °C
3.1: 50 percent / H2O / 72 h / 20 °C
View Scheme
参考文献
Skaff, Ojia; Jolliffe, Katrina A.; Hutton, Craig A.
Journal of Organic Chemistry, 2005 , vol. 70, # 18 p. 7353 - 7363
反应条件
1: 92 percent / Pd(dppf)Cl2*CH2Cl2; KOAc / dimethylsulfoxide / 4.5 h / 80 °C
2: 50 percent / H2O / 72 h / 20 °C
View Scheme
参考文献
Skaff, Ojia; Jolliffe, Katrina A.; Hutton, Craig A.
Journal of Organic Chemistry, 2005 , vol. 70, # 18 p. 7353 - 7363
反应条件
sodium periodate; ammonium acetate in water; acetone
T=20°C; Oxidation; 48 h;
参考文献
Nakamura, Hiroyuki; Fujiwara, Masaru; Yamamoto, Yoshinori
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 1 p. 231 - 235
反应条件
1: 99.8 percent / triethylamine / CH2Cl2 / 28 h / 0 - 20 °C
2: 58 percent / Et3N / [PdCl2(PPh3)2] / dioxane / Heating
3: NaIO4; NH4OAc / acetone; H2O / 48 h / 20 °C
View Scheme
参考文献
Nakamura, Hiroyuki; Fujiwara, Masaru; Yamamoto, Yoshinori
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 1 p. 231 - 235
反应条件
1: 96 percent / Cs2CO3 / methanol; dimethylformamide / 2 h / 20 °C
2: 82 percent / Et3N / [PdCl2(dppf)] / dioxane / 100 °C
3: NaIO4; NH4OAc / acetone; H2O / 48 h / 20 °C
View Scheme
参考文献
Nakamura, Hiroyuki; Fujiwara, Masaru; Yamamoto, Yoshinori
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 1 p. 231 - 235
反应条件
1: 5 percent / Et3N / [PdCl2(dppf)] / dioxane / 80 °C
2: NaIO4; NH4OAc / acetone; H2O / 48 h / 20 °C
View Scheme
参考文献
Nakamura, Hiroyuki; Fujiwara, Masaru; Yamamoto, Yoshinori
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 1 p. 231 - 235
反应条件
1: 58 percent / Et3N / [PdCl2(PPh3)2] / dioxane / Heating
2: NaIO4; NH4OAc / acetone; H2O / 48 h / 20 °C
View Scheme
参考文献
Nakamura, Hiroyuki; Fujiwara, Masaru; Yamamoto, Yoshinori
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 1 p. 231 - 235
反应条件
1.1: aq. K2CO3 / toluene / 6 h / 20 °C
2.1: potassium carbonate; tetrabutylammonium iodide / acetone / 0.5 h / 20 °C
2.2: 2.86 g / acetone / 2 h / Heating
3.1: 92 percent / Pd(dppf)Cl2*CH2Cl2; KOAc / dimethylsulfoxide / 4.5 h / 80 °C
4.1: 50 percent / H2O / 72 h / 20 °C
View Scheme
参考文献
Skaff, Ojia; Jolliffe, Katrina A.; Hutton, Craig A.
Journal of Organic Chemistry, 2005 , vol. 70, # 18 p. 7353 - 7363
